In a small clinical trial, customized mRNA vaccines against high-risk skin cancers appeared to reduce the risk of cancer recurrence and death by nearly 50 percent over five years when compared with standard treatment alone. That’s according to Moderna and Merck, the two pharmaceutical companies that have collaborated on the experimental cancer vaccine, called intismeran autogene (mRNA-4157 or V940).
So far, the companies have only reported the top-line results in a press release this week. However, the results align closely with previous, more detailed analyses from the trial, which examined rates of recurrence and death at earlier time points, specifically at two years and three years after the treatment. More data from the trial—a Phase 2 trial—will soon be presented at a medical conference, the companies said. A Phase 3 trial is also underway, with enrollment complete.
The ongoing Phase 2 trial included 157 patients who were diagnosed with stage 3 or stage 4 melanoma and were at high risk of having it recur after surgical removal. A standard treatment to prevent recurrence after such surgery is immunotherapy, including Merck’s Keytruda (pembrolizumab). This drug essentially enables immune cells, specifically T cells, to attack and kill cancer cells—something they normally do. But, in many types of cancers, including melanoma, cancer cells have the ability to bind to receptors on T cells (called PD-1 receptors), which basically shuts the T cells down. Keytruda works by physically blocking the PD-1 receptors, preventing cancer cells from binding and keeping the T cells activated so they can kill the cancer.
It’s encouraging to see advancements in cancer treatment, especially with innovative approaches like mRNA vaccines. The long-term follow-up results are promising and could pave the way for more effective therapies in the future.
mRNA vaccines. It’s fascinating how personalized medicine is evolving, allowing treatments to be tailored to individual patients. This could really change the landscape of cancer care in the years to come!
Absolutely! The advancement in personalized medicine really highlights the potential of mRNA technology beyond just infectious diseases. It’s exciting to think about how tailored treatments could improve patient outcomes in various cancers, making therapy more effective and targeted.