Mewgenics has been in the public eye for more than a decade. Super Meat Boy developer Team Meat initially announced it in 2012, before canceling it in 2016. When McMillen and the Super Meat Boy developer parted ways, McMillen retained the rights to the game and decided to completely rework it, first exploring prototypes in 2018 with The End is Nigh co-developer Tyler Glaiel.

